People

Faculty Members

James Ware

James is a Reader in Genomic Medicine at Imperial College, and a group head within the Cardiovascular Genetics & Genomics Unit. He practices clinically as a Consultant Cardiologist at Royal Brompton & Harefield Hospitals, where he is research lead for Inherited Cardiac Conditions. He also holds a visiting scientist position at the Broad Insitute of MIT & Harvard in Boston, MA.
j.ware@imperial.ac.uk
http://www.imperial.ac.uk/people/j.ware
@drjamesware

Stuart Cook

Stuart is Professor of Clinical & Molecular Cardiology at Imperial College London and group head within the Cardiovascular Genetics & Genomics Unit. He is also Director of the Cardiovascular & Metabolic Disorders Programme at Duke-NUS Medical School, Singapore, and Director of the National Heart Research Institute of Singapore.
stuart.cook@imperial.ac.uk
https://www.imperial.ac.uk/people/stuart.cook
@stuartacook1

Paul Barton

Paul Barton is Honorary Senior Research Fellow at Imperial College and Genetics Research Manager at the Royal Brompton Hospital. His research interests include gene-environment interaction, noncoding RNA, and enhancing international collaboration, currently through research partners based in Florence, Madrid and the Aswan Heart Centre in Egypt.
p.barton@imperial.ac.uk
https://www.imperial.ac.uk/people/p.barton
@pjrbarton

Team Members

Rachel Buchan

Rachel is a molecular biologist with an interest in the genetics of inherited cardiac conditions. She oversees the wet-lab based projects in the Cardiovascular Genetics and Genomics Group at the Royal Brompton.
Rachel.buchan@imperial.ac.uk

Ben Corden

Ben is an NIHR Post-doctoral Academic Clinical Fellow and Specialist Registrar training in cardiology. He is currently investigating genetic influences on arrhythmias in dilated cardiomyopathy.
b.corden@imperial.ac.uk

Catherine Enright
Catherine is the Cardiovascular Genetics & Genomics Research Group Manager, responsible for the day to day operation and administration of the Group including finance, grants and HR and contributes to strategic planning.
Catherine previously worked for the British Heart Foundation then joined Imperial College to manage the Cardiac Medicine BHF Chair Department. She moved to central NHLI Section Administration, supporting cardiovascular groups at St Mary’s and South Kensington campuses before returning to Royal Brompton. She joined the Group in 2019.
c.enright@imperial.ac.uk
Mikyung Jang

Mikyung is Senior Bioinformatician and Systems Administrator for the group. The latter part is for the Brompton cluster. She is interested in mitochondrial contribution to cardiovascular disease.

Katherine Josephs

Kat is a specialist registrar in Clinical Genetics and a Clinical Research Fellow in the Cardiovascular Genetics and Genomics group. She is interested in inherited cardiac conditions and plans to pursue a PhD to investigate the genetics of paediatric cardiomyopathy.
kjosephs@imperial.ac.uk

melpi
Melpi Kasapi

Melpi is a PhD student working on developing machine learning methods for patient stratification and survival prediction in cardiomyopathies. She is a using a combination of genomic and cardiac magnetic resonance (CMR) data to construct clinically informative machine and deep learning models, and identify important genetic and CMR features for cardiomyopathies.

Nicholas Li

Nick is a PhD student working on bioinformatic methods for identifying novel-missense variants that are likely pathogenic by using information from paralogous genes. Additionally, he is also looking into specific variants associated with Hypertrophic cardiomyopathies (HCM) and is evaluating variant interpretation techniques for these variants using patient outcome data.
nicholas.li12@imperial.ac.uk

Francesco Mazzarotto

Francesco is a Honorary Research Associate primarily based at the University of Florence (Italy), where he is a post-doctoral bioinformatician. His current research is mainly focused on understanding the genetic architecture of cardiomyopathies through the analysis of cohorts and families, on developing algorithms that aid the identification of pathogenic variation and contribute to a refinement of current variant interpretation approaches.
f.mazzarotto@imperial.ac.uk
https://www.imperial.ac.uk/people/f.mazzarotto
@franz_mazz

Kathryn McGurk

Kathryn is a Research Associate Bioinformatician funded by the BHF Centre of Excellence to Imperial College London, primarily analysing the UK Biobank exome sequencing data to aid genetic and phenotypic interrogation of the dataset.
k.mcgurk@imperial.ac.uk
@KathrynMcGurk

Anne Marie Moody

Anne is using genome engineering to model cardiomyopathies in stem-cell derived cardiomyocytes.

Katie O'Fee

Katie is research technician based in the molecular biology laboratory at the Hammersmith Campus. She supports the wet-lab based projects of the group and is currently investigating the role of IL-11 in fibrosis and ageing.

Jemilat Orlandy

Jemilat is a Band 6 Clinical Research Nurse within the Cardiovascular Genetics and Genomics Group at Imperial College. She supports the recruitment and informed consent of patients with Inherited Cardiac Conditions at the Royal Brompton and Harefield Hospitals. Current research she is working on aims to identify new interventions to treat and prevent inherited cardiomyopathies, focusing specifically on hypertrophic and dilated cardiomyopathies.

Nick Quaife

Nick is a Clinical PhD Fellow, working in the molecular biology laboratory at the Hammersmith Campus.  He is interested in heart failure and arrhythmia, and is investigating the role of novel biomolecules in myocardial fibrosis.

CatherineR
Catherine Renwick

Catherine is a HEE/NIHR Pre-doctoral clinical academic fellow and Consultant Nurse in Paediatric Electrophysiology and Inherited Cardiovascular Conditions at Royal Brompton Hospital. Catherine’s research interest lies in the safety of exercise monitoring and prescription for children diagnosed with arrhythmias, particularly inherited arrhythmias.
crenwick@ic.ac.uk

Angharad Roberts

Angharad is a Clinical Geneticist with a subspecialist interest in cardiac conditions; and a postdoctoral research fellow in the Cardiovascular Genetics and Genomics Group.  She is interested in the diagnosis of complex cases, delineating and understanding the variability in clinical expression of recognised syndromes (expanding the phenotype) and identifying new syndromes and diagnoses to inform both clinical practice and research.

Chulin Sha

Chulin is a research associate bioinformatician with the NHLI, currently working on non-coding variants in cardiomyopathy, exploring their pathogenicity and mechanism using WGS data. This will hopefully expand our understanding and to improve diagnosis.

Paz Tayal

Dr. Paz Tayal is a Post doctoral Clinical Lecturer studying the imaging and genetics of cardiomyopathies. Upasana is working on integrating genetic, imaging, and multiparametric phenotyping data to explore gene-environmental interactions, improve risk stratification and identify predictors of remodelling in patients with dilated cardiomyopathy.
u.tayal@rbht.nhs.uk
u.tayal14@imperial.ac.uk
@doctor_paz

 

Pantazis Theotokis

Pantazis Theotokis is a research assistant in bioinformatics interested in developing and implementing new pipelines for the analysis of NGS data in cardiomyopathies. He is currently working on ways to improve integration and harmonisation of genetic variants from various cohorts.

Konstantinos Vanezis

Konstantinos is a NHLI post-doctoral associate, working in the molecular biology laboratory at the Hammersmith Campus. He is interested in cardiac fibrosis and is investigating the role of IL-11 in fibrosis using a variety of models.

Xiao Xu

Xiao is a postdoctoral bioinformatician, interested in using NGS technologies to understand genetic cause of cardiovascular disorders. Current projects involve discovery of monogenic and polygenic disease causing variants from family and case-control association studies.

Xiaolei Zhang

Xiaolei is a research assistant interested in the statistical learning methods to facilitate variant interpretation in cardiovascular disease. She is now working on new statistical models to predict variant’s pathogenicity.
xiaolei.zhang@imperial.ac.uk

Alumni